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February 27 嘿嘿Dear Jie:
On behalf of CSSS Director Dan Rockmore, I am pleased to inform you that you have been selected to participate in the Complex Systems Summer School in Santa Fe, New Mexico from June 2 through June 27, 2008. You have been chosen from among many qualified applicants because of your unusually strong application. We hope that you will accept this invitation to attend the school.
No tuition is charged for the program. We will also cover your housing and meals for the duration of the school.
We are able to offer you a travel scholarship up to the amount of US$1,200 toward the purchase of an economy-class round-trip airline ticket on a U.S.-flag air carrier to attend the summer school. We expect that you will make your own travel arrangements to Santa Fe. Please submit your original travel receipts when we request them at the start of the session in Santa Fe, and based on the receipt we will reimburse your expense up to the amount of $1,200 at the end of the school.
**Please note that if you are not a U.S. citizen, we will reimburse your costs based on visa eligibility. Our visa coordinator will contact you in the coming month to provide you with information about U.S. visa policies and requirements. Compliance with visa requirements, if applicable, is a condition of attending the CSSS.**
You should plan to arrive in Santa Fe on Sunday, June 1 and to depart on Saturday, June 28. Please note that the closest major airport to Santa Fe is the Albuquerque International Sunport. Sandia Shuttle Express (http://www.sandiashuttle.com/Schedules.html) will take you from the airport directly to St. John's College in Santa Fe, where you will be staying. Reservations are strongly recommended because of the busy tourist season.
To accept this invitation and reserve your space at the school, you must register online at http://www.santafe.edu/education/application/csss08_santafe no later than Friday, April 4.
Please introduce yourself to other participants by posting a picture and short biography to the CSSS wiki at http://www.santafe.edu/events/workshops/index.php/CSSS_2008_Santa_Fe-Participants after creating your own login.
Congratulations on your acceptance, and we look forward to seeing you this summer in Santa Fe. In the meantime, if you have any questions, please do not hesitate to contact me.
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发现自己不知道该说些什么,有点小激动,唉,知道Santa Fe的朋友应该还是能理解我的。我不敢妄称自己是朝圣者,但Santa Fe确是Complexity的圣城。
不想多说什么,事情多,忙去了,嗷嗷。 February 18 两岸猿声啼不住,轻舟已过万重山在找IkappaB的ubiquitinylation rate时,无意发现的,A. E. Motter的近作, 跟Barabasi合作的。 Barabasi转做生物以不是新闻了,主要方向是medical research,有了好几篇高水平的关于drug的文章,当然也有关于gene regulation, metabolism的。 不过Motter转生物让人吃惊不小,西北大学现在似乎是个hub了,不知道以后他的主方向是否生物。不过既然是做同步出生的,现在出来这篇FBA做代谢网络的文章也在情理之中。毕竟同步跟FBA的相似度跟复杂网络的其他领域比起来是最大的。动作可真快。 有时间,先仔细看看这篇文章,然后考虑下跟DFBA的联系:) February 15 昨天google的logoFebruary 13 用网络工具预测大选结果与股票价格
February 04 显微镜下的美丽世界不论我们喜不喜欢眼前的物体,眼睛永远用同一种方式采集信息:视网膜上的细胞捕捉光子,将其中的信息传递给大脑,再由大脑还原为画面。如果物体太小,反射的光子过少,肉眼就无法看清它的结构。这时,我们需要借助显微技术进行观察。本文展示的图片,均是2007年奥林巴斯生物数字成像大赛(Olympus BioScapes Digital Imaging Competition)的获奖作品,不仅具有重要的学术价值,更有强烈的艺术美感。这些图片代表了生物研究中最先进的光学显微技术。
复杂的大脑:美国加利福尼亚大学圣迭戈分校的托马斯·迪林克(Thomas Deerinck)利用双光子显微技术(2-photon microscopy),拍摄到了一块仅有400μm厚的小鼠小脑组织样本的精细显微结构(见下图),其中绿色的是浦肯野神经细胞(Purkinje neuron),红色的是神经胶质细胞(glial cell),蓝色的则是神经核。
美国哈佛大学的吉恩·里维特(Jean Livet)使用共焦显微技术(confocal microscopy),拍摄了一只基因工程小鼠的脑干组织切片(厚340μm)。由于经过基因改造,小鼠的每个神经细胞都呈现出不同的颜色(见下图)。给神经元赋予不同的颜色(即“脑虹”技术,Brainbow),科学家就能观察到单个轴突在复杂的脑神经网络中的走向。
因为所在空间狭小且不易分离,内耳结构极难观察。美国北卡罗来纳大学惠明顿分校的索尼娅·派奥特(Sonja Pyott)拍摄到了小鼠内耳毛细胞(最左边),这些细胞可将机械声波转换成电脉冲信号。图中,毛细胞为绿色,与毛细胞有突触联系的细胞为红色,蓝色的则是细胞核(共焦显微技术)。
美国华盛顿大学的格伦·麦克唐纳德(Glen MacDonald)采用相似的染色方法,拍摄到一只小鼠内耳的组织结构图(共焦显微技术)。
肌细胞构成了坚韧的肌肉组织。下图所展示的,正是小鼠舌头肌肉的横截面,由美国加利福尼亚大学圣迭戈分校的托马斯·迪林克(Thomas Deerinck)拍摄。
下图则出自德国明斯特大学的赫尔曼·阿伯利(Hermann Aberle)之手,显示了被显微镜放大的果蝇肌肉纤维。由于基因变异,果蝇的肌肉纤维看上去杂乱无章(共焦显微技术)。
鱼鳍与山羊骨:两张图片所展示的,都是构成脊椎动物身体结构的致密组织。以色列拉马特甘市的沙穆埃尔·西尔贝曼(Shamuel Silberman)把一条小鱼的鱼鳍骨放大了100倍,于是就有了右边这幅斑驳的秋景(采用光纤照明技术)。
为了观察骨形成期骨密度的变化以及矿物质含量的增加程度,美国佛罗里达州坦帕市莫菲特癌症中心的马克·劳埃德(Mark Lloyd)和诺埃尔·克拉克(Noel Clark)把山羊骨放大了4倍(广野显微技术)。
在细胞分裂间期,杜克大学的U·塞尔达尔·图卢(U. Serdar Tulu)在138μm宽的视野中,拍摄到了染色体(蓝色)周围正在形成的微管(黄色)
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