原打算3天内把Z要的文章写完，然后舒舒服服的回家休息。不想翻遍了硬盘，移动硬盘，邮箱，都找不到原来写了一半的Tex了。啊啊啊，郁闷，这样一来，不但文章要重新写，还要重新做完所有的计算，太背了~~~哭。在瑞士的工作都做了3个备份，就独独忘了这个tex :( 不过还好，程序还在，3天累点，估计还是能完成的。真是不爽，还好有bbs，可以上去愤青愤青一把，发泄一下.嘿嘿

照片也翻出来来，也空把瑞士的游记也弄弄:)

In vivo (Latin: (with) in the living) means that which takes place inside an organism. In science, in vivo refers to experimentation done in or on the living tissue of a whole living organism.
In vitro (Latin: (with) in the glass) refers to the technique of performing a given experiment in a test tube, or, generally, in a controlled environment outside a living organism.
In silico is an expression used to mean "performed on computer or via computer simulation." The phrase is coined from the Latin phrases in vivo and in vitro that are commonly used in biology (see also systems biology) and refer to experiments done in living organisms and outside of living organisms, respectively. Contrary to widespread belief, in silico does not mean anything in Latin.
History of the term in silico:
The expression In silico was first used in public in 1989 in the workshop "Cellular Automata: Theory and Applications" in Los Alamos, New Mexico. Pedro Miramontes, a mathematician from National Autonomous University of Mexico (UNAM) presented the report "DNA and RNA Physicochemical Constraints, Cellular Automata and Molecular Evolution". In his talk, Miramontes used the term "In silico" to characterize biological experiments carried out entirely in a computer. The work was later presented by Miramontes as his PhD dissertation.[1]

in silico has been used in White Papers written to support the creation of bacterial genome programs by the Commission of the European Community. The first refereed paper where "in silico" appears was written by a French team in 1991.[2]

in silico versus in silicio

"In silico" was briefly challenged by "in silicio", which is correct Latin for "in silicon" (the Latin term for silicon, silicium, was created at the beginning of the 19th Century by Berzelius). "In silico" was perceived as catchier, possibly through similarity to the word "silicate". "In silico" is now almost universal; it even occurs in a journal title (In Silico Biology: http://www.bioinfo.de/isb/)

The phrase "in silico" originally applied only to computer simulations that modeled natural or laboratory processes (in all the natural sciences), and did not refer to calculations done by computer generically.

references:
[1] Miramontes P. Un modelo de autómata celular para la evolución de los ácidos nucleicos. Tesis de doctorado en matemáticas. UNAM. 1992.
[2]  Danchin A, Medigue C, Gascuel O, Soldano H, Henaut A. From data banks to data bases. Res Microbiol. 1991 Sep-Oct;142(7-8):913-6. PMID 1784830

以后欧要做的咚咚大致都算in silico的范畴了。才开始看到Palsson新书的第3章，无意中从电脑里翻出汤雷翰老师以前的一个ppt，才发现里面讲代谢网络in silico的部分，大都来之Palsson的网页，汗一个先。。。越发崇拜Palsson了.

In silico以后绝对应该是systems biology的主流（或者现在已经是了？） 下面是关于E-cell project的一个介绍 http://e-cell.org

Is reconstruction of life in silico possible? This naïve question lead a handful of our young scientists and students to start the E-Cell project with the ultimate goal of simulating the whole cell. It was 1995 when the first " blue print of life", the complete genome sequences of Haemophilus influenzae and Mycoplasma genitalium, became available. Yes, we were naïve at that time. We thought that major bottleneck of this grand challenge would be CPU power and manpower. While those remain to be major obstacles, we are facing many other major scientific challenges. Now over 70 people are working on the E-Cell project. Some are working in the areas of bioinformatics such as Simulation Science and Knowledge Engineering. Some are working in data-driven Systems Biology such as Metabolome, Proteome, Transcriptome and Interactome. And some are working in modeling cells such as red blood cell, neural cell, myocardial cell, bacterial cell and plant cell.

 

刚把哈肯的《协同学》看完，终于明白这门所谓的学科为什么死掉了:)

David G.Myers的《社会心理学》，精读到第8章，还剩一半:( 不过倒是明白了很多道理。

Palsson的新书《Systems Biology: Properties of Reconstructed Networks》，是windwin扫描，传给我，然后打印出来看的:)十分感谢.

H. Risken的《The Fokker-Planck Equation: Methods of Solution and Applications》，这本书是一定要拿着草稿纸，一步一步自己演算的，虽然现在才看到第3章，但收获的知识不少。

图书馆只剩最后一本了，借了过来。不过后来在ftp上弄到了电子版，我已转化为pdf版，15M的样子，有需要的可要在MSN上找我要哈:)

今天刚收到的DHL:

关于money那块真是太吸引人了...

1) Tuition Fee, university miscellaneous fees such as computer fees, sport facilities fees and insurance subsidies on a yearly basis throughout the period of the award.   Value: In full.

2) An annual book allowance.   Value: S$500.

3) A one-time laptop allowance.   Value: S$1000.

4) Group Medical Insurance on a yearly basis.     Value: S$200.

5) Conference allowance (reimbursement basis, subject to written approval).    Value: up to S$3000.

6) Stipend on a yearly basis (S$3200*12).    Value: S$38,400.

四点查DHL状态时，居然发现3点时就到了，不过地址错误，不能签收。愣

赶快上网找电话，google，baidu一到关键时候就哑了，最后还是在bbs上找到，赶紧一个电话，然后3分钟就送到了

真要赞一下DHL的服务，哈哈。

 

最后，顺便赞一下Risken那本关于Fokker-Planck的书，这几天看的好爽:)