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September 29 about pathway modelingAlthough the chemical reactions are determinate, we can derive the noise term directly from the master equation (like Langevin, Fokker-Planck) by taking the second order approximation, considering the discreteness of molecule. Moreover, the random birth and death of molecules provides the intra-noises and the enviroment perturbation induces the extra-noises. Therefore, we can study the effect of noise on the cell signaling pathway, just like before, the study of noise effect in nonlinear dynamics.
In another aspect, the pathway modeling is always considered in individual cells and there are already many excellent and burdensome works. If I want to do some different work to take up my own field, it is necessary to open a new different door.
That should be cell-cell communication, in my opinion. Considering some signaling molecules' diffusion to couple intercellular signaling pathways, we can investigate the effect of noises (stochastic fluctuations, correlation of intra-extra noise), the effect of diffusion (complex coupling scheme, heterogenous contact), just like the study in interacting oscillators. It sounds interesting.
Anyway, I will think and read this more after the bored midterm. September 09 Fiona Fung 冯翠桦听到一首旋律不错的曲子，《我在那一角落患过伤风》。全曲居然只有darling这一个歌词。。。。。。 |
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